Efficacy and safety of domestic amphotericin B in preemptive therapy of pulmonary invasive fungal infection in hematological disorder patients

Abstract

Abstract: Objective To observe the therapeutic efficacy and adverse reactions of domestic amphotericin B in the treatment of invasive fungal infection (IFI) in hematological disorder patients.Methods A total of 45 cases of immunodepressive IFI patients receive domestic amphotericin B treatment from December 2004 to December 2008 in our hospital were retrospectively analyzed.Result All the cases patients received amphotericin B therapy for more than 2 weeks,in which the longest was 14 weeks,with 6 weeks as median.The total effective rate was 86.7%.Adverse reaction included hypokalemia,fever,aminotransferase,kidney failure,and gastrointestinal reactions.Conclusions Domestic amphotericin B is affirmed in the preemptive therapy for IFI in hematological patients with tolerable adverse reactions.

Key words: amphotericin B, hematological disorder, invasive fungal infection, preemptive therapy

CLC Number:

R756.6

CHAI Jun-yue, WEI Na, CUI Ting-ting, XU Lan-ping, HUANG Xiao-jun. Efficacy and safety of domestic amphotericin B in preemptive therapy of pulmonary invasive fungal infection in hematological disorder patients[J]. Chinese Journal of Mycology, 2010, 5(3): 144-147.

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