Serum interleukin-17 after bronchopulmonary infection by Candida albicans in rats

Abstract

Abstract: Objective To investigate the changes and significance of serum interleukin 17 (IL-17) in bronchiopulmonary infection of Candida albicans in rats.Methods Immunocompromised rat model was set up with glucocorticoid injection.Model rats were administered with Candida albicans suspension and salines through tracheal intubation as positive group and negative control group.Candida albicans suspension was also administered to healthy rats as experimental group.Blood was collected bia the tail vein 1,3,5,7 days after infection for serum IL-17 detection by ELISA; Rats were sacrificed after 7 days and the right lower lung tissue was removed for HE staining.Results The serum levels of IL-17 in the experimental group at day 3 and 5 were higher than those in the control group.But no significant difference was observed at day 1 and 7 among the three groups (P>0.05).Pathology showed significant inflammation of lung in the experimental grou,but mild in the positive group.Inflammatory cell infiltration was not found in the control group.Conclusions IL-17 may participate in the inflammatory response by promoting neutrophil accumulation in the airway and the level is related to the body inflammation.IL-17 plays an important role in fungal infection-mediated inflammation of respiratory tract.

Key words: interleukin-17, Candida albicans, lung, infection

CLC Number:

R379.4

CHEN Yao-hua, WANG Li, MENG Xin-li, ZHOU Yang-yang, LIN Li. Serum interleukin-17 after bronchopulmonary infection by Candida albicans in rats[J]. Chinese Journal of Mycology, 2010, 5(5): 264-268.

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