Abstract: Objective To explore the clinical and laboratory features of leg ulcer caused by Fusarium moniliforme.Methods Characteristics of Fusarium moniliforme was observed by microscopy and fungal culture.Pathological examination was performed for diagnosis.Results White and cottony mould colony grew on PDA agar at 25℃ with sickle-like macroconidia,concatenate and capitulum-like microconidium under microscope and scanning electron microscope.The fungi was identified as F.moniliforme with the ability growing at 25℃ and 37℃ on Sabrous agar.Chroic granuloma was found,but no fungal components were observed by PAS or silver staining.The lesions were cured after voriconazole and terbinafine treatment combined with debridement and skingrafting.Conclusions A case of leg ulcer caused by Fusarium moniliforme was diagnosed and cured by combination therapy of voriconazole with surgery.

Key words: Fusarium moniliforme, ulcer, voriconazole