Abstract: Objective To determine the susceptibilities of Trichophyton mentagrophytes strains and to evaluate the M38-A2 scheme of CLSI.Methods Thirty-eight isolates of Trichophyton interdigitale(T.interdigitale) and 6 isolates of Trichophyton anamorph of A.benhamiae strains from 8 different regions of China were included and the MICs to fluconazol(FLU),itraconazole(ITR), voriconazole(VIR), terbinafine(TER),griseofulvin(GRI),ciclopiroxolamine(CIC),bifonazole(BIF),and amorofine(AMO) were determined by M38-A2 scheme.Results MICs(μg/mL) of T.interdigitale and A.benhamiae to FLU,ITR,VIR,TER,GRI,CIC,BIF,AMO were 0.25～32,0.031 2～1,0.015 6～0.062 5,0.000 937～0.007 81,0.062 5～1,0.031 2～2,1～2,0.007 81～0.062 5(T.interdigitale) and ≥64,2,0.25～0.5,0.000 937～0.003 81,1,2～4,1～2,0.031 2～0.062 5(A.benhamiae) respectively.There were significant differences in the sensitivities to FLU,ITR,VIR,GRI and CIC,but no significants were found in the sensitivities to TER,AMO and BIF.Conclusions M38-A2 scheme could be applied to determine the susceptibility of T.mentagrophytes to antifungal drugs with good reproducibility and feasibility.

Key words: Trichophyton mentagrophytes, susceptibility test, M38-A2 scheme