Abstract: Objective To observe the effect of lumbar drainage catheter and intrathecal injection of amphotericin B on the early treatment of cryptococcal meningitis,and to investigate the clinical feasibility.Methods Clinical data of 4 patients with cryptococcal meningitis under lumbar drainage catheter treatment was collected and analyzed.Results After early treatment of lumbar drainage catheter and intrathecal injection of amphotericin B,3 patients were cured without recurrence and the other one was significanly improved.Conclusions Lumbar drainage catheter combined with intrathecal injection of amphotericin B in early treatment of cryptococcal meningitis is efficient in the reduction of high CSF pressure and the improvement of clinical symptoms.

Key words: cryptococcal meningitis, lumbar drainage catheter, intrathecal injection