A case of mixed bloodstream infection of Trichosporon asahii and Magnusiomyces clavatus in a patient with bone marrow transplantation

Abstract

Abstract: A 40-year-old female patient with myelodysplastic syndrome had recurrent fever after bone marrow transplantation. Blood culture showed that the bloodstream was infected with 2 strains of fungi. 18S ribosomal RNA (18S rRNA) sequencing results showed that one of the fungi was Trichosporon assahii and the other was Magnusiomyces clavatus. The two fungi were rare fungi, both sensitive to voriconazole. Due to the long time of identification and drug sensitivity, the patient did not wait for the adjustment of reasonable antifungal drugs, and died due to persistent neutropenia and fungemia. This case was the first report in Chinese of bloodstream mixed infection of Trichosporon asahii and Magnusiomyces clavatus in patients with hematological diseases.

Key words: Trichosporon asahii, Magnusiomyces clavatus, haematological patients, rare yeasts, rapid diagnosis

CLC Number:

R519.8

LI Jixia, MIN Yan. A case of mixed bloodstream infection of Trichosporon asahii and Magnusiomyces clavatus in a patient with bone marrow transplantation[J]. Chinese Journal of Mycology, 2023, 18(4): 340-343.

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