Pathogenic distribution characteristics of fungal bloodstream infection in Sichuan Province from 2019 to 2021

Chinese Journal of Mycology　2023, Vol. 18 　Issue (3): 198-204,210.

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Pathogenic distribution characteristics of fungal bloodstream infection in Sichuan Province from 2019 to 2021

DENG Jin¹, YIN Lin², JIANG Haiyan³, KUANG Linghan⁴, PENG Xi⁵, YANG Xianggui⁶, NI Sujiao⁷, ZHANG Bangqin⁸, FENG Jinfang⁹, WANG Yanling¹⁰, MA Yushan¹¹, CHEN Zongyao¹², ZHONG Hanyu¹³, WU Xianli¹⁴, LI Kun¹⁵, WANG Ling¹⁶, GAO Wei¹⁷, YANG Xueqiang¹⁸, ZHU Jun¹⁹, CHEN Yu²⁰, ZHANG Xian²¹, SUN Changjun²², LUO Jun²³, LI Yumei²⁴, LI Yan²⁵, ZHANG Bin²⁶, XIE Ning²⁷, WANG Jun²⁸, XIE Yi¹, KANG Mei¹

1. Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610000;
2. Sichuan Provincial People's Hospital, Chengdu 610000;
3. Guang'an People's Hospital, Guang'an 638500;
4. West China Second Hospital of Sichuan University, Chengdu 610000;
5. Chengdu Third People's Hospital, Chengdu 610000;
6. The First Affiliated Hospital of Chengdu Medical College, Chengdu 610000;
7. Sichuan Cancer Hospital, Chengdu 610000;
8. Affiliated Hospital of Southwest Medical University, Luzhou 646000;
9. Guangyuan Central Hospital, Guangyuan 628000;
10. Leshan People's Hospital, Leshan 614000;
11. Mianyang Third People's Hospital, Mianyang 621000;
12. Deyang City People's Hospital, Deyang 618000;
13. Neijiang First People's Hospital, Neijiang 641000;
14. Panzhihua Central Hospital, Panzhihua 617000;
15. Suining Central Hospital, Suining 629000;
16. Xichang Municipal People's Hospital, Xichang 615000;
17. Ya'an Municipal People's Hospital, Ya'an 625000;
18. Yibin Second People's Hospital Yibin 644000;
19. Ziyang First People's Hospital, Ziyang 641300;
20. Zigong First People's Hospital Zigong 643000;
21. Chengdu Second People's Hospital, Chengdu 610000;
22. Dazhou Central Hospital, Dazhou 635000;
23. Mianyang Central Hospital, Mianyang 621000;
24. Zigong Fourth People's Hospital, Zigong 643000;
25. Meishan People's Hospital, Meishan 620000;
26. Nanchong City Central Hospital, Nanchong 637000;
27. Affiliated Hospital of North Sichuan Medical College, Nanchong 637000;
28. Panzhihua Hospital of Integrated Traditional Chinese and Western Medicine, Panzhihua 617000

Received:2022-05-06 Online:2023-06-28 Published:2023-07-08

Abstract

Abstract: Objective To collect the fungal bloodstream infection data from the Sichuan Provincial Center of China Fungal Disease Surveillance System, to analyze the distribution characteristics and the susceptibility to antifungal drugs of pathogens, and to provide epidemiological data for fungal bloodstream infections in Sichuan Province. Methods The data of outpatient, emergency, and inpatient fungal bloodstream infections in 28 hospitals from January 1, 2019, to December 31, 2021, were studied. The clinical and laboratory data of fungal bloodstream infection were analyzed using Whonet 5.6 and Microsoft Excle pivot table. information. Results From January 1, 2019, to December 31, 2021, Candida accounted for 88.8% (1083/1 220) of the 1 220 fungal strains was reported by 28 hospitals. Candida albicans was the main species, accounting for 35.3% (431/1 220).and Cryptococcus neoformans being fifth in the total number of isolates, accounting for 8.3% (101/1 220). Males accounted for 56.6% (690/1 220), and female patients were less (43.4%, 530/1 220); 79.8% cases were middle-aged and elderly patients (>46 years old) and 34.8% cases were from the intensive care unit. C. albicans had the highest sensitivity to fluconazole (85.7%); resistance rates of C.tropicalis to fluconazole and voriconazole were 43.4% and 43.3%, respectively. by C. albicans isolates were dominated in Most hospitals, however, C. parapsilosis was mostly isolated in children's specialized hospitals. Conclusion The pathogens of fungal bloodstream infection and their antifungal drug susceptibility have regional characteristics. Accurately grasping the epidemiological data in the region can provide a basis for the clinical selection of antifungal drugs.

Key words: fungal bloodstream infection, pathogenic fungi, antifungal drug susceptibility, distribution characteristics, epidemiology

CLC Number:

R 519

DENG Jin, YIN Lin, JIANG Haiyan, KUANG Linghan, PENG Xi, YANG Xianggui, NI Sujiao, ZHANG Bangqin, FENG Jinfang, WANG Yanling, MA Yushan, CHEN Zongyao, ZHONG Hanyu, WU Xianli, LI Kun, WANG Ling, GAO Wei, YANG Xueqiang, ZHU Jun, CHEN Yu, ZHANG Xian, SUN Changjun, LUO Jun, LI Yumei, LI Yan, ZHANG Bin, XIE Ning, WANG Jun, XIE Yi, KANG Mei. Pathogenic distribution characteristics of fungal bloodstream infection in Sichuan Province from 2019 to 2021[J]. Chinese Journal of Mycology, 2023, 18(3): 198-204,210.

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Pathogenic distribution characteristics of fungal bloodstream infection in Sichuan Province from 2019 to 2021

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