Retrospective analysis of Kodamaea ohmeri infection in Asia from 2002 to 2022

Abstract

Abstract: Objective To analyze epidemiological trends and clinical characteristics of cases caused by Kodamaea ohmeri in Asia, and to provide a scientific basis for improving the clinical diagnosis and treatment of K. ohmeri infections. Methods Using the methods of literature review and meta-analysis to analyze retrospectively the information of patient’s nationality, sex and aged composition, risk factors, onset organs, clinical manifestations, therapeutic methods and prognosis of K. ohmeri. Results K. ohmeri infections could occur in both immunocompetent and immunocompromised person. The gender ratio of the infection host was 1.59:1, predominantly in premature neonate and middle aged people, and the blood system was the most commonly affected site. More than half of the patients had immunodeficiency diseases or other risk factors, and there were no early specific symptom with chief complaints of fever. Diagnosis of K. ohmeri infections mainly relied on culture. The patients had a poor prognosis, with high mortality. Conclusion The incidence of K. ohmeri infections has increased recently and the diagnosis mainly depends on culture. Strengthening the in vitro antifungal susceptibility monitoring and the studying of epidemiology for K. ohmeri are significant to improve the diagnosis and prognosis of K. ohmeri infections.

Key words: Kodamaea ohmeri, epidemiology, clinical characteristics

CLC Number:

R519.8

ZHU Xinlin, LI Chen, HU Dongying, CHEN Xianzhen, JIANG Weiwei, LIU Yinuo, CHEN Tianyang, CHEN Tiancheng, LIAO Wanqing, LIU Xiaogang, PAN Weihua. Retrospective analysis of Kodamaea ohmeri infection in Asia from 2002 to 2022[J]. Chinese Journal of Mycology, 2023, 18(2): 123-129.

References

[1] IOANNOU P, PAPAKITSOU I. Kodamaea ohmeri infections in humans:A systematic review[J].Mycoses,2020,63(7):636-643.
[2] KURTZMAN C P, KREGER-VAN R. The yeast taxonomic study[M]. Amsterdan:Elsevier Science Publishers, 1984:273.
[3] ZHOU M, LI Y, KUDINHA T, et al. Kodamaea ohmeri as an emerging human pathogen:A review and update[J]. Front Microbiol,2021,12:736582.
[4] CHAKRABARTI A, RUDRAMURTHY S M, KALE P, et al. Epidemiological study of a large cluster of fungaemia cases due to Kodamaea ohmeri in an Indian tertiary care centre[J]. Clin Microbiol Infect, 2014,20(2):O83-O89.
[5] 刘彩霞,杨锦红,董琳,等,奥默毕赤酵母菌致早产儿医院获得性败血症的临床特点及同源性分析[J].中华医学杂志,2013,93(4):285-288.
[6] 刘德美,安玉亮,苏芬.奥默毕赤酵母菌引起脓血尿一例报道[J].中华检验医学杂志,2002,25(1):31.
[7] 黄志刚.从一例患者的血液中检出奥默毕赤酵母菌[J].中华检验医学杂志,2002,25(4):225.
[8] SHIN D H, PARK J H, SHIN J H, et al. Pichia ohmeri fungemia associated with phlebitis:successful treatment with amphotericin B[J]. J Infect Chemother,2003,9(1):88-89.
[9] OTAG F, KUYUCU N, ERTURAN Z, et al. An outbreak of Pichia ohmeri infection in the paediatric intensive care unit:case reports and review of the literature[J]. Mycoses,2005,48(4):265-269.
[10] TAJ-ALDEEN S J, DOIPHODE S H, HAN X Y. Kodamaea (Pichia) ohmeri fungaemia in a premature neonate[J]. J Med Microbiol,2006,55(Pt 2):237-239.
[11] OSTRONOFF F, OSTRONOFF M, CALIXTO R, et al. Pichia ohmeri fungemia in a hematologic patient:an emerging human pathogen[J]. Leuk Lymphoma,2006,47(9):1949-1951.
[12] LEE J S, SHIN J H, KIM M N, et al. Kodamaea ohmeri isolates from patients in a university hospital:identification, antifungal susceptibility, and pulsed-field gel electrophoresis analysis[J]. J Clin Microbiol,2007,45(3):1005-1010.
[13] MAHFOUZ R A, OTROCK Z K, MEHAWEJ H, et al. Kodamaea (Pichia) ohmeri fungaemia complicating acute myeloid leukaemia in a patient with haemochromatosis[J]. Pathology,2008,40(1):99-101.
[14] POOJARY A, SAPRE G. Kodamaea ohmeri infection in a neonate[J]. Indian Pediatr, 2009,46(7):629-631.
[15] CHIU C H, WANG Y C, SHANG S T, et al. Kodamaea ohmeri fungaemia successfully treated with caspofungin[J]. Int J Antimicrob Agents,2010,35(1):98-99.
[16] YANG B H, PENG M Y, HOU S J, et al. Fluconazole-resistant Kodamaea ohmeri fungemia associated with cellulitis:case report and review of the literature[J]. Int J Infect Dis,2009,13(6):e493-e497.
[17] MENON T, HERRERA M, PERIASAMY S, et al. Oral candidiasis caused by Kodamaea ohmeri in a HIV patient in Chennai, India[J]. Mycoses,2010,53(5):458-459.
[18] 唐杨烽,徐激斌,徐志云, 等.风湿性心脏瓣膜病合并活动期真菌性心内膜炎的手术治疗1例报告[J].第二军医大学学报,2010,31(9):958.
[19] SHANG S T, LIN J C, HO S J, et al. The emerging life-threatening opportunistic fungal pathogen Kodamaea ohmeri:optimal treatment and literature review[J]. J Microbiol Immunol Infect,2010,43(3):200-206.
[20] QIN Y H,WU W W,Liu Y, et al. Isolation, identification, and antifungal susceptibility test for Kodamaea ohmeri:a case report on endocarditis[J]. Journal of Medical Colleges of PLA,2010,25(4):252-256.
[21] 张春玲,徐德祥,王立生, 等.卡泊芬净成功治愈奥默柯达真菌血症1例[J].中国医药导报,2011,8(31):149-151.
[22] AL-SWEIH N, KHAN Z U, AHMAD S, et al. Kodamaea ohmeri as an emerging pathogen:a case report and review of the literature[J]. Med Mycol,2011,49(7):766-770.
[23] SUNDARAM P S, BIJULAL S, THARAKAN J A, et al. Kodamaea ohmeri tricuspid valve endocarditis with right ventricular inflow obstruction in a neonate with structurally normal heart[J]. Ann Pediatr Cardiol,2011,4(1):77-80.
[24] XIAO Y L, KANG M, TANG Y, et al. Kodamaea ohmeri as an emerging pathogen in mainland China:3 case reports and literature review[J]. Laboratory Medicine, 2013,44(suppl_1):e1-e9.
[25] DAS K, BHATTACHARYYA A, CHANDY M, et al. Infection control challenges of infrequent and rare fungal pathogens:lessons from disseminated Fusarium and Kodamaea ohmeri infections[J]. Infect Control Hosp Epidemiol,2015,36(7):866-868.
[26] BISWALD, SAHU M, MAHAJAN A, et al. Kodameae ohmeri-An emerging yeast:Two cases and literature review[J]. J Clin Diagn Res,2015,9(3):DD01-DD3.
[27] 曹海明,黄伯湘,毛思颖, 等.奥默毕赤酵母菌感染致人工生物瓣膜心内膜炎一例[J].中华心血管病杂志,2016,44(1):72-73.
[28] 马心锋,胡文彬,王共强, 等.卡泊芬净治愈肝豆状核变性合并奥默毕赤酵母菌感染1例并文献复习[J].安徽医学,2016,37(2):136-139.
[29] NI B, GU W, MEI Y, et al. A rare life-threatening Kodamaea ohmeri endocarditis associated with hemophagocytic lymphohistiocytosis[J]. Rev Esp Cardiol (Engl Ed), 2018,71(1):51-53.
[30] KANNO Y, WAKABAYASHI Y, IKEDA M, et al. Catheter-related bloodstream infection caused by Kodamaea ohmeri:A case report and literature review[J]. J Infect Chemother, 2017,23(6):410-414.
[31] TASHIRO A, NEI T, SUGIMOTO R, et al. Kodamaea ohmeri fungemia in severe burn:Case study and literature review[J]. Med Mycol Case Rep,2018,22:21-23.DOI:10.1016/j.mmcr.2018.07.005.
[32] JEFFREY P H, KUEN-J T, JOHNSON LIN. Unusual fungemia in a patient with metastatic gastric cancer[J]. J Cancer Surviv,2018,5(4):172-174
[33] SAUD AL-ABBAS A H, LING J L, MUHAMMED J, et al. Rare Kodamaea ohmeri keratitis following a trivial vegetative trauma[J]. BMJ Case Rep,2019,12(6):e229660.
[34] YU Q, YAN J, GAO Z, et al. Subcutaneous granuloma caused by Kodamaea ohmeri in an immunocompromised patient in China[J]. Australas J Dermatol,2020,61(2):e213-e216.
[35] HOU C. Catheter-related bloodstream infection caused by Kodamaea ohmeri in China[J]. Infect Prev Pract,2019,1(1):100006.
[36] JAYAWEERA JAAS, KOTHALAWALA M, SOORIYAR S. Infected tricuspid valve myxoma with Kodamaea ohmeri:Case report[J]. Indian J Med Microbiol,2021,39(2):252-255.
[37] WANG C H, SU Y S, LEE W S. Necrotizing cellulitis caused by Kodamaea ohmeri fungemia in a HIV-infected patient[J]. J Infect,2022,S0163-4453(22):00008-1.
[38] PANDE A, NON L R, ROMEE R, et al. Pseudozyma and other non-Candida opportunistic yeast bloodstream infections in a large stem cell transplant center[J]. Transpl Infect Dis,2017,19(2). DOI:10.1111/tid.12664.
[39] BERGMAN M M, GAGNON D, DOERN G V. Pichia ohmeri fungemia[J]. Diagn Microbiol Infect Dis,1998,30(3):229-231.
[40] HAN X Y, TARRAND J J, ESCUDERO E. Infections by the yeast Kodomaea (Pichia) ohmeri:two cases and literature review[J]. Eur J Clin Microbiol Infect Dis,2004,23(2):127-130.
[41] ZHOU M, YU S, KUDINHA T, et al. Identification and antifungal susceptibility profiles of Kodamaea ohmeri based on a seven-year multicenter surveillance study[J]. Infect Drug Resist,2019,12:1657-1664.DOI:10.2147/IDR.S211033.