Analysis of clinical distribution and drug resistance of Candida in a hospital in Inner Mongolia from 2012 to 2021

Abstract

Abstract: Objective To analyze the distribution and drug resistance of Candida in a hospital in Inner Mongolia from 2012 to 2021, so as to provide evidence for clinical management of Candida infection. Methods The distribution and drug susceptibility test results of Candida strains in a hospital from January 2012 to December 2021 were retrospectively analyzed. Results A total of 5472 strains of Candida were isolated. The samples were mainly from urine, sputum and secretions, accounting for 41.28%, 31.69% and 11.22%, respectively. The distribution of clinical departments was mainly from health ward, respiratory and critical care ward and ICU, accounting for 27.54%, 18.29% and 17.71%, respectively. The drug resistance rates of Candida albicans, C. tropicalis, C. paracalbicans, C. glabrata, C. nameless, C. krondo and C. Portugal to 5-flucytosine, amphotericin B, voriconazole, fluconazole and itraconazole were 0.14%-3.53%, 0.39%-22.41%, 0-2.82%, 0-12.5%, 0%, 0.53%-5.88%, 1.05%-57.895% and 0-12.22% respectively. The change of drug resistance of C. albicans was not obvious. Conclusions C. albicans had been the most common candida in our hospital from 2012 to 2021, but the proportion of C. albicans isolated in 2020 and 2021 showed a downward trend, while non-Candida albicans showed an upward trend. Among C. tropicalis isolated in our hospital, the resistance rate to triazole antifungal drugs was high in C.tropicalis, and the resistance rates to 5-flucytosine and itraconazole were the highest in C. kronoris except for the natural resistance to fluconazole, while the resistance rates of other Candida strains were low.

Key words: Candida, clinical distribution, drug resistance monitoring, change trend

CLC Number:

R519.3

LI Min, ZHAO Jianping, FENG Jiangtao. Analysis of clinical distribution and drug resistance of Candida in a hospital in Inner Mongolia from 2012 to 2021[J]. Chinese Journal of Mycology, 2023, 18(2): 104-110.

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