Clinical and laboratory analysis of bloodstream infection caused by Candida tropicalis

Abstract

Abstract: Objective To analyze the clinical characteristics and laboratory results of bloodstream infection caused by Candida tropicalis in order to provide reference for clinical and prevention. Methods The clinical data of patients with bloodstream infection caused by Candida tropicalis in West China Hospital Sichuan University from January 2018 to December 2020 were collected, and the related clinical characteristics and laboratory examination of the patients were analyzed retrospectively. Results The 27 patients with bloodstream infection caused by Candida tropicalis had basic diseases and two or more risk factors. (1,3)-β-D-glucan test had a good sensitivity in the auxiliary diagnosis of Candida tropicalis bloodstream infection. Other inflammatory indexes such as high sensitive C-reactive protein, procalcitonin and interleukin-6 were increased in varying degrees.The sensitivity rates of 27 strains of Candida tropicalis to azole antifungal drugs were itraconazole(77.8%),voriconazole(48.2%), fluconazole(48.2%), posaconazole(37.0%). The sensitivity rate to amphotericin B, caspofungin and micafungin was 100%. Conclusion Candida tropicalis bloodstream infection often occured in patient with underlying diseases and a variety of risk factors Candida tropicalis had poor sensitivity to azole drugs, so we should pay attention to drug sensitivity results in clinical treatment.

Key words: Candida tropicalis, bloodstream infection, clinical characteristics, laboratory examination

CLC Number:

R379.4

CHENG Wei, DENG Jing, LIU Ya, SHU Ling, CHEN Zhixing, DAI Zhongqiu, KANG Mei. Clinical and laboratory analysis of bloodstream infection caused by Candida tropicalis[J]. Chinese Journal of Mycology, 2022, 17(2): 99-102,114.

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