Pulmonary tuberculosis combined infection with two strains of Aspergillus fumigatus with different phenotypes

Abstract

Abstract: The patient was a 69-year-old male patient. He had recurrent coughing and sputum production for 8 months, with aggravated hemoptysis for 4 days. The patient had pulmonary tuberculosis 7 years ago, he was cured after 1 year of anti-tuberculosis treatment. Mycobacterium tuberculosis was detected by metagenomic second-generation sequencing of bronchoscopy lavage samples. Serum and bronchoscopy lavage fluid Aspergillus antigen galactomannan tests were positive. Two forms of Aspergillus fumigatus (white strain and typical smoke-green strain)were cultured from bronchoscopy lavage fluid .The two strains had the same susceptibility test results and high degree of homology. The patient was diagnosed as tuberculosis combined with invasive Aspergillus fumigatus infection. Anti-tuberculosis and voriconazole were given. Regular follow-up review of chest CT and sputum smear for acid-fast bacilli were recommended after discharged.

Key words: tuberculosis, Aspergillus fumigatus complex, albino strain, fungal drug sensitivity

CLC Number:

R519.8

WANG Shuling, LI Yanmin, ZHANG Zhen, WANG Liying, YAN Ling, XU Lanlan, LIAO Pu. Pulmonary tuberculosis combined infection with two strains of Aspergillus fumigatus with different phenotypes[J]. Chinese Journal of Mycology, 2022, 17(1): 44-48.

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