Osteolytic lesion caused by disseminated Talaromyce marneffei infection in a HIV negative patient

Abstract

Abstract: Talaromyce marneffei(T.marneffei)is a dimorphic fungal.There were rare reports of T.marneffei caused osteolytic destruction in non-HIV-infected cases. A patient who came from Guangxi Zhuang Autonomous Region, presented with fever, shoulder pain, weight loss, osteolytie lesion. He was HIV-negative, physical health, and did not merge the underlying disease with immune impairment. Pus of left shoulder joint and blood culture were positive for T.marneffei, His clinical status was improved and discharged after a month of amphotericin B treatment. The patient had 3 readmissions for other reasons within 2 years later. The last admitting diagnosis was septic shock.He died 6 months later due to co-infection of Mycobacterium avium-intracellulare complex (MAC) and T.marneffei probably.

Key words: Talaromyces marneffei, HIV negative, osteolytic lesion

CLC Number:

R519.8

HUANG Chunlan, WEI Wenfei, MA Limei. Osteolytic lesion caused by disseminated Talaromyce marneffei infection in a HIV negative patient[J]. Chinese Journal of Mycology, 2021, 16(6): 410-413.

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