Abstract: Objective To investigate the related factors of mixed Candida/bacterial bloodstream infections in children. Methods The clinical data of 225 children with Candida bloodstream infection from March 2013 to June 2020 were reviewed. The related factors of mixed Candida/bacterial bloodstream infection were analyzed by univariate and multivariate analysis. Results The incidence of mixed Candida/bacterial bloodstream infection was 29.33%. Univariate analysis showed that gestational age (<37 weeks), birth weight (<2 500 g), age of onset (<7 D), amniotic fluid pollution, intrauterine distress, apagar score (<7 points), type of infection (hospital infection), length of stay in NICU (≥7 days), premature rupture of membranes, hospitalization time (≥14 days), invasive treatment, AP 14 factors such as ache Ⅱ score (≥15 points), the number of antibiotics replaced (≥3 kinds), serum albumin (<30 g/L) were the related factors of neonatal mixed Candida/bacterial bloodstream infection (P<0.05) Multivariate analysis showed that gestational age (<37 weeks), type of infection (nosocomial infection), length of stay in NICU (≥7 days), length of hospital stay (≥14 days), invasive treatment, Apache Ⅱ score (≥15 points) and the number of antibiotics changed (≥3 kinds) were independent risk factors of neonatal mixed Candida/bacterial bloodstream infection (P< 0.05). Conclusion The main measures to reduce the new mixed bloodstream infection are to reduce the hospitalization time, stay in NICU, frequently change antibiotics and invasive diagnosis and treatment, strengthen the prevention and control of nosocomial infection and reduce the occurrence of nosocomial infection, rationally use antibiotics and reduce blind multiple replacement of antibiotics, and pay attention to the treatment of low weight and critical children.

Key words: neonatal, mixed Candida/bacterial, bloodstream infection, factor analysis