In vitro antifungal activity of domestic posaconazole against pathogenic fungi isolated from genital candidiasis

Abstract

Abstract: Objective To determine the in vitro antifungal activity of domestic posaconazole against the clinical isolates isolated from genital candidiasis. Methods We used the CLSI (Clinical and Laboratory Standards Institute) broth microdilution method M27-A4 to evaluate the minimal inhibitory concentration (MIC) of posaconazole and other common antifungal agents against 60 clinical isolates of Candida spp. Results The MIC range, geometric mean (GM), MIC₅₀ and MIC₉₀ of posaconazole against fluconazole-resistant C. albicans strain is 0.25-0.50 μg/mL, 0.40 μg/mL, 0.5 μg/mL and 0.5 μg/mL respectively. The data changed to 0.03-0.125 μg/mL, 0.10 μg/mL, 0.125 μg/mL and 0.125 μg/mL when posaconazole against C. parapsilosis. To C. tropicalis, the MIC range, GM, MIC₅₀ and MIC₉₀ is 0.125-8.0 μg/mL, 0.57 μg/mL, 0.5 μg/mL and 2 μg/mL respectively. To C. glabrata, the MIC range, GM, MIC₅₀ and MIC₉₀ is 0.06-2.0 μg/mL, 0.25 μg/mL, 0.125 μg/mL and 1 μg/mL respectively. And the MIC range and GM of posaconazole against C. krusei is 0.125-0.50 μg/mL and 0.29 μg/mL. The MIC₅₀ and MIC₉₀ of posaconazole against C. krusei is 0.25 μg/mL and 0.5 μg/mL, respectively. Conclusions Posaconazole is active against the fluconazole-resistant strains and non-albicans Candida strains associate with genital candidiasis.

Key words: antifungal agent, posaconazole, in vitro susceptibility tests, genital candidiasis

CLC Number:

R978.5

TAN Jingwen, GAO Zhiqin, YANG Hong, YANG Lianjuan. In vitro antifungal activity of domestic posaconazole against pathogenic fungi isolated from genital candidiasis[J]. Chinese Journal of Mycology, 2021, 16(5): 326-329,334.

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