Abstract: Objective To find the effect of cinnamaldehyde on the growth and biofilm formation of Trichosporon asahii(T. asahii). Methods Clinical isolates were selected for gene sequencing and VITEK MS identification, and the biofilm model was established in vitro. The inhibitory effects of cinnamaldehyde at 1050 mg/L, 525 mg/L, 262.5 mg/L and 131.25 mg/L on the growth of T. asahii were determined by multiple dilution method.The effects of different concentrations of cinnamaldehyde on the biofilm formation of T. asahii. were observed by silver staining method. Results Each concentration of cinnamaldehyde could affect the growth of T. asahii and prolong the formation time of biofilm. The higher the concentration of cinnamaldehyde, the more obvious the effect was. When the concentration of cinnamaldehyde reached 1050 mg/L, the inhibition effect of cinnamaldehyde on the growth of T. asahii was the most significant, the growth of T. asahii was not observed in the medium wells at the concentration. Silver staining showed that no biofilm was formed in the medium at this concentration, indicating that the concentration of cinnamaldehyde at 1050mg/L had a significant inhibitory effect on the formation of biofilm of T. asahii. Conclusion Cinnamaldehyde can affect the growth and biofilm formation of T. asahii.

Key words: cinnamaldehyde, Trichosporon asahii, biofilm