Distribution and epidemic trend of Candida isolates from patients with oral candidiasis

Abstract

Abstract: Objective To analyze the distribution and epidemic trend of Candida isolates from oral candidiasis patients in our hospital in recent five years retrospectively. Methods A total of 27,162 saliva culture samples collected from the Mucosal Department of Peking University Hospital of Stomatology between 2015 and 2019 were retrospectively analyzed. All the results were entered into the Excel form and analyzed in groups according to different species distribution, funged quantities, sexes and ages. Results Among all the Candida strains isolated from oral candidiasis patients from 2015 to 2019, Candida albicans accounted for the highest proportion, while the positive proportion of Candida tropicalis and other Candida increased year by year. In the samples infected by C. albicans, C. tropical and C. glabrata, the number of colonies was mainly ≥200 CFU/mL. However, the number of colonies in samples infected with C. kruseii and other Candida species is mainly ≤30 CFU/mL or ≥200 CFU/mL. In all study populations, the positive rate of infection in female patients was significantly higher than that in male patients (P<0.05), and the positive rate of oral infection generally increased with age and increased significantly after the 41~50 age group. Conclusion Although Candida albicans was still the main pathogen of oral Candida infection, the positive rate of Candida tropicalis and other Candida had been increasing year by year in recent years. The analysis of the distribution and epidemic trend of oral candidiasis might be useful for clinical medication strategy.

Key words: oral cavity, fungal infection, Candida, species distribution

CLC Number:

R379.4

SONG Yang, HE Jing, HE Chun. Distribution and epidemic trend of Candida isolates from patients with oral candidiasis[J]. Chinese Journal of Mycology, 2021, 16(3): 166-169,181.

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