A case report of Alternaria alternate-induced cutaneous alternariosis in a patient with pulmonary sarcoidosis

Abstract

Abstract: Female, 61-year-old, diagnosed with pulmonary sarcoidosis and treated with oral glucocorticoid for a period of 7 months. She was presented with red plaque in both dorsal hands and wrists for 3 months. Histology revealed mild acanthosis, mixed infiltration of neutrophils, lymphocytes, plasma cells and multinuclear giant cells was found in the superficial and middle dermis. Importantly, Scattered yeast-like structures with thick wall were noted in dermis. Irregular swollen hyphae and yeast-likes spore with thick wall were observed in Grocott's stain. In addition, brownish greycolony was isolated from the lesion. Brown septate spores were observed under microscopy. The colony was identified as Alternaria alternate by ITS sequencing. Oral itraconazole(200 mg/day) and topical sertaconazole nitrate cream (twice per day) were prescribed for 4 months. The lesions were subsided and no flare at half year follow-up.

Key words: Alternaria alternata, cutaneous alternariosis, sarcoidosis, glucocorticoid

CLC Number:

R519.8

GUO Yanyang, HAI Luming, SUN Xiaoran, YAN Dong, ZHU Guannan, WANG Lei, WANG Gang, FU Meng. A case report of Alternaria alternate-induced cutaneous alternariosis in a patient with pulmonary sarcoidosis[J]. Chinese Journal of Mycology, 2021, 16(2): 121-124.

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