Dynamic changes of blood routine and immune function in patients with fungal esophagitis during antifungal therapy

Abstract

Abstract: Objective To analyze the dynamic changes of blood routine and immune function in patients with fungal esophagitis. Methods Fourty-two cases of mycotic esophagitis in our hospital were included in the experimental group, and the patients were given fluconazole and clotrimazole antifungal treatment; 42 cases of reflux esophagitis in the same period were included in the control group, and given routine treatment. Blood routine examination and immune function monitoring were carried out dynamically in the two groups at the time of admission, 1, 3, 5, 7 and 14 days after treatment. During the treatment, adverse reactions were observed. Results During the treatment, the white blood cell count in the experimental group showed a downward trend, while the percentage of neutrophils showed an upward trend; in the control group, the white blood cell count showed a downward trend, and there were no significant changes in the neutrophil count. There were significant differences in WBC count among the groups on 1 d, 3 d, 5 d, 7 d, 14 d after treatment (P<0.05); on admission, on 1 d, 3 d, 5 d, 7 d, the neutrophil comparison between the groups was significant (P<0.05), while on the 14th day of treatment, there were no significant differences in the percentage of neutrophils among the groups (P>0.05). CRP levels in the experimental group and the control group showed a downward trend, and there were significant differences between the two groups on the 1st, 3rd, 5th, 7th and 14th days of treatment (P<0.05); the IgM and IgG of the experimental group and the control group were increased, and the differences between the two groups were statistically significant (P<0.05). Conclusions Most of the patients with fungal esophagitis had decreased immune function and neutrophil ratio. During the treatment, routine blood test and dynamic monitoring of immune function could provide clinical basis for curative effect evaluation of patients with fungal esophagitis.

Key words: fungal esophagitis, antifungal therapy, blood routine examination, immune function

CLC Number:

R571
R519

ZHANG Chunmei, ZHAO Ting, HE Xiaoli, PENG Lei. Dynamic changes of blood routine and immune function in patients with fungal esophagitis during antifungal therapy[J]. Chinese Journal of Mycology, 2021, 16(2): 106-110.

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