Abstract: We report a case of refractory sporotrichosis due to the abuse of oral glucocorticoid. A 61-year-old female patient had a stab wound on the right wrist and was diagnosed as sporotrichosis. After antifungal treatment for six months, her condition deteriorated and came to our hospital for treatment. Fungal microscopy, culture, molecular biology detection and the pathological examination were performed and the results support the diagnosis of sporotrichosis. When asking about the medical history, it was found that the patient had the habit of taking oral glucocorticoid tablets on a daily basis. The patient was instructed to stop the glucocorticoid and take oral itraconazole for 4 months and was successfully cured eventually.

Key words: sporotrichosis, oral glucocorticoid, treatment