Species distribution and antifungal susceptibility test of invasive Candida infection in a hospital in Beijing

Abstract

Abstract: Objective To investigate the species distribution and antifungal susceptibility of invasive candida infection in a hospital in Beijing, and to provide evidence for rational use of antifungal drugs. Methods Totally 126 strains of invasive candida isolates were collected from the hospital during 2012-2013 and 2016-2017, and the composition of the strains were analyzed. The susceptibility of 7 antifungal drugs was analyzed by microbroth dilution method. Results Of the 126 Candida strains, C.albicans was the most predominant, accounting for 38.10%. Of the non-C.albicans strains, C.glabrata was the most common with a frequency of 30.95%, followed by C.tropicalis (18.25%) and C.parapsilosis (11.11%), respectively. The susceptibility (wild type) rates of C.albicans and C.parapsilosis to amphotericin B and echinomycins were close to 100%. The resistance (non wild type) rates of C.glabrata and C.tropicalis to fluconazole (10.26% and 30.43%) and voriconazole (48.72% and 26.09%) were showed in higher levels, while the susceptibility (wild type) rates of C.glabrata and C.tropicalis to amphotericin B and echinomycins were >92%. Conclusion The frequency of non-C.albicans in invasive Candida infection was up to 61.90%. Amphotericin B and echinomycins could be used for the empirical treatment of invasive Candida infection, while azoles should be used with caution for C.glabrata and C.tropicalis infections.

Key words: invasive Candida infection, species distribution, antifungal susceptibility test

CLC Number:

R519.3

YANG Jing-xian, SHAO Dong-hua, GUO Li-na, LIU Jing, Xu Ying-chun, LIANG Guo-wei. Species distribution and antifungal susceptibility test of invasive Candida infection in a hospital in Beijing[J]. Chinese Journal of Mycology, 2020, 15(6): 359-363,370.

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