Analysis of distribution and drug resistance of clinical Candida strains in 497 cases

Abstract

Abstract:

Objective To explore the type, distribution and drug resistance of inpatient's Candida infection in Shenyang, so as to provide theoretical basis for clinical prevention and rational drug use of Candida infection. Methods The clinical data of Candida strains isolated from inpatients in Sheng Jing Hospital affiliated to China Medical University from 2015 to 2018 were collected retrospectively, and the data and results of strain identification and drug sensitivity test were statistically analyzed. Results A total of 497 strains of Candida were detected, of which the main strains were Candida parapsilosis (175, 35.2%), followed by Candida albicans (127, 25.6%), Candida pelliculosa (51, 10.3%), Candida glabrata (42, 8.5%) and Candida tropicalis (36, 7.2%). The distribution of the strains was statistically different (P=0.004). The hosts were mainly of patients aged 0-9 and 50-69 years old. In 497 strains of Candida, the isolates of from blood was accounted for 81.5%,followed by those from hydrothorax or ascitic fluid (4.2%), drainage fluid (4.2%) cerebrospinal fluid (1.4%) and urine were (1.4%). There was significant difference in the distribution of strains among different types of samples (P=0.003). The resistance rates of clinical common Candida to fluconazole, voriconazole, flucytosine, itraconazole, and amphotericin B were 3.0%, 2.2%, 4.0%, 5.0% and 4.0%, respectively. Conclusion The infection of Candida albicans in hospital was the most common. In the treatment of newborns, elderly patients and patients with digestive system diseases, we should be alert to the occurrence of double infection of Candida.

Key words: Candida, drug sensitivity test, drug resistance

CLC Number:

R519.3

WANG Jun-ting, LIU Yong. Analysis of distribution and drug resistance of clinical Candida strains in 497 cases[J]. Chinese Journal of Mycology, 2020, 15(2): 78-82.

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