Epidemiology, antifungal drugs susceptibilities and prognosis of catheter-related candidemia in cardiovascular disease patients

Abstract

Abstract:

Objective To analyze the pathogenic epidemiological data of intravascular catheter-associated candidemia and the prognosis of patients. Methods Laboratory and clinical data of patients with catheter-related candidemia in AnZhen hospital from 2012 to 2017 were collected, and statistical analysis was conducted on the distribution of pathogenic bacteria, sensitivity of antifungal drugs, antifungal treatment and prognosis data. Results 71 subjects were included. A total of 27 patients with catheter-related candidemia were diagnosed, 51.9%(14) of which were elderly patients. Candida albicans accounted for 48.1%(13)of all the isolates. The susceptibility rate of all isolates to antifungal drugs that commonly used on clinic was above 90%. Compared with patients that undergo no bloodstream infection,patients with catheter-related candidemia have much more decline on Barthel index(-27.8 vs -13.5, P=0.00),longer length of hospitalization stay(40.0 days vs 12.8, P=0.00),longer length of ICU stay(14.4 days vs 2.3, P=0.00),much more hours of respirator support(318.4 vs 25.9, P=0.00), and less proportion of recovery or improvement(P=0.02,Fisher's Exact Test). Conclusion Catheter-associated candidemia is mainly occur in elderly patients. Candida albicans take the most place of the pathogenic isolates. Yeast colonize on the skin or in vivo may be the main source of infection. Catheter-related candidemia can significantly affect the prognosis of patients and aggravate the burden of medical care. Reasonable preventive measures should be taken to prevent the occurrence of catheter-related candidemia.

Key words: catheter-related candidemia, species distribution, drug susceptibility, prognosis

CLC Number:

R519.3

LIU Yu-lei, LIU Mei-qing, WANG Li, YUAN Hui, GUO Li-na. Epidemiology, antifungal drugs susceptibilities and prognosis of catheter-related candidemia in cardiovascular disease patients[J]. Chinese Journal of Mycology, 2020, 15(1): 37-42.

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