Analysis the pathogen distribution and drug susceptibility of yeast bloodstream infection in Peking Union Medical College Hospital from 2014 to 2018

Abstract

Abstract:

Objective To analysis the pathogen distribution and drug susceptibility of yeast blood stream infection, to provide the basis for clinical diagnosis and treatment. Methods Clinical data of Candida blood stream infection was retrospectively analyzed in in Peking Union Medical College Hospital from January 2014 to December 2018. Results A total of 206 non-repetitive yeast strains were isolated from blood culture specimens. The positive isolation rate of yeast from Bactec Mycosis IC/F bottle, aerobic and anaerobic blood culture bottle were 1.32% (79/6003), 0.43%(371/85855)and 0.06% (47/77168) respectively. The top three Candida species were Candida albicans (72, 34.95%), Candida tropicalis (42, 20.39%) and Candida glabrata (39, 18.93%). The uncommon Candida species included Candida guilliermondii, Pichia pastoris, Candida lusitaniae, Saccharomyces cerevisiae, Candida lambica, Candida nivalis, Rhodotorula and Candida Haemulonii. In our hospital,candidemia usually developed in patients aged >60 years (42.23%) and was mostly in men (115, 55.83%). Infected patients were mainly from the emergency department (41, 19.90%), surgery intensive care unit and internal intensive care unit (both were 36, 17.48%). The positive alarm times from long to short was:Candida glabrata, Candida parapsilosis, Candida albicans and Candida tropicalis. The susceptibility rates of Candida albicans, Candida glabrata, Candida parapsilosis and Candida tropicalis to fluconazole were 98.61%、97.44%、89.66% and 71.43%, respectively. Conclusion Candida albicans was the main blood stream infection species in our hospital. Most Candida strains had high sensitivity to antifungal drugs, but the resistance rate of Candida tropicalis was relatively high.

Key words: Candida, blood stream infection, antifungal susceptibility test

CLC Number:

R519.3

LIU Wen-jing, SUN Hong-li, ZHANG Xiao-jiang, YANG Wen-hang, XIAO Meng, WANG Yao, YANG Qi-wen, DOU Hong-tao, WANG He, ZHAO Ying, GUO Li-na, LIU Ya-li, ZHANG Li, ZHU Ren-yuan, XU Ying-chun. Analysis the pathogen distribution and drug susceptibility of yeast bloodstream infection in Peking Union Medical College Hospital from 2014 to 2018[J]. Chinese Journal of Mycology, 2019, 14(6): 357-361.

References

[1] Ruiz-Ruigómez M, Dueñas C, Hernandez C, et al. Clinical predictors of candidemia in medical non-neutropenic, non-ICU patients. The CaMed score[J]. Int J Clin Pract,2018,72(12):e13275.
[2] Pfaller MA, Diekema DJ, Turnidge JD, et al. Twenty years of the SENTRY Antifungal Surveillance Program:results for Candida species from 1997-2016[J]. Open Forum Infect Dis,2019,6(Suppl 1):S79-S94.
[3] Enoch DA, Yang H,Aliyu SH, et al. The Changing epidemiology of invasive fungal infections[J]. Methods Mol Biol,2017,1508:17-65.
[4] Arendrup MC. Candida and candidaemia. susceptibility and epidemiology[J]. Dan Med J,2013,60(11):B4698.
[5] Wang H, Xu YC, Hsueh PR. Epidemiology of candidemia and antifungal susceptibility in invasive Candida species in the Asia-Pacific region[J]. Future Microbiol,2016,11:1461-1477.
[6] 荣辰,田素飞,褚云卓. 326株念珠菌血症病原菌种分布和药敏结果分析[J]. 中国医科大学学报,2018,47(9):773-777.
[7] Ericson EL,Klingspor L, Ullberg M, et al. Clinical comparison of the Bactec Mycosis IC/F, BacT/Alert FA, and BacT/Alert FN blood culture vials for the detection of candidemia[J]. Diagn Microbiol Infect Dis,2012,73(2):153-156.
[8] 曹云,宋少婷,李帅,等. 念珠菌血流感染临床与实验室特点分析[J]. 中国真菌学杂志,2019,14(1):7-10.
[9] 顾海彤,黄艳飞,孙宇峰,等. 不同种类微生物血培养阳性报警时间的临床意义探讨[J]. 中国实验诊断学,2011,15(11)1882-1884.
[10] Köck R, Eiing LC, Boschin MG, et al. Evaluation of bactec mycosis IC/F and Plus Aerobic/F blood culture bottles for detection of Candida in the presence of antifungal agents[J]. J Clin Microbiol,2013,51(11):3683-3687.
[11] 余小丽,陈愉生,林晟,等. 真菌血流感染病原菌分布及对抗真菌药的敏感性分析[J]. 海峡药学,2017,29(12):141-142.
[12] Xiao M, Sun ZY, Kang M, et al. Five-year national surveillance of invasive candidiasis:species distribution and azole susceptibility from the China Hospital Invasive Fungal Surveillance Net (CHIF-NET) Study[J]. J Clin Microbiol,2018,56(7):e00577-18.

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