Distribution characteristics of invasive fungal infections in Hebei province from 2016 to 2017

Chinese Journal of Mycology　2019, Vol. 14 　Issue (5): 257-263.

Distribution characteristics of invasive fungal infections in Hebei province from 2016 to 2017

LI Fang¹, LI zhi-rong², ZHAO Jian-hong², ZHAO Ying³, ZHANG Yan-hai⁴, DONG Ai-ying⁵, LIU Jin-lu⁶, GUO Yan-yan⁷, SUN Yan⁸, ZHAO Wen-shen⁹, XIE Shou-jun¹⁰, WEI Hong-lian¹¹, ZHANG Jin-yan¹², REN Hong-tao¹³, WANG Jian-sheng¹⁴, WU Xiang-kun⁴, GUANG Xiao¹⁵, LI Dong-qing¹⁶, DU Hong-li¹⁷, GUO Ying-hui¹⁸, XU Ying-chun³, XIAO Meng³, YANG Wen-Hang³, XU Xiao-lin⁴

1. Herbei Yanda hopstial, Langfang 065201;Chao yang Hospital Affilliated to the Capital University of Medical Science, Beijing 100020, China;
2. Clinical Laboratory Center of Hebei Province, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China;
3. Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China;
4. Herbei Yanda hopstial, Langfang 065201;
5. North China University of Science and Technology Affiliated Hospital, Tangshan 063000;
6. The First Affiliated Hospital of Hebei North University School of Clinical Medicine, Zhangjiakou 075000;
7. Department of Endocrinology, Tangshan Gongren Hospital, Tangshan 063000;
8. Cangzhou Central Hospital, Cangzhou 061001;
9. The Central Hospital of Handan, Handan 056001;
1
0. Affiliated Hospital of Chengde Medical College, Chengde 067000;
1
1. The Second Hospital of Hebei Medical University, Shijiazhuang 050000;
1
2. Fourth Hospital Affiliated to Hebei Medical University, Shijiazhuang 050019;
1
3. People's Hospital of Xingtai City, Xingtai 054001;
1
4. Hebei Provincial People's Hospital, Shijiazhuang 050057;
1
5. The First People's Hospital of Wu'an City, Wuan 056300;
1
6. Handan First People's Hospital, Handan 056002;
1
7. People's Hospital of Hengshui City, Hengshui 053000;
1
8. Hebei Children's Hospital, Shijiazhuang 050030

Received:2019-06-13 Online:2019-10-28 Published:2019-10-28

Abstract

Abstract:

Objective To expore distribution characteristics of invasive fungal infections in 16 tertiary teaching hospitals in Hebei from 2016 to 2017, and to provide data for clinical diagnosis, treatment and infection control. Methods The yeast fungi and filamentous fungi causing invasive fungal infections were collected by member units. The strains were re-examined by Vitek MS analysis in the central laboratory. For difficult and rare strains, ITS and/or calmodulin CaM sequencing were used. Results A total of 493 invasive fungi strains were detected in 16 hospitals from 2016 to 2017, including 268 yeast fungi (54.36%) and 225 filamentous fungi (45.64%). Yeast fungi include 112 strains of C. albicans (41.79%), 52 strains of C. tropicalis (19.40%), 38 strains of C. parapsilosis (14.18%), 29 strains of C. glabrata (10.82%), 10 strains of Cryptococcus neoformans (3.73%) and 27 strains of other Candida (10.07%). Filamentous fungi included 131 strains of Aspergillus fumigatus (58.22%), 24 strains of Aspergillus flavus/Aspergillus oryzae (10.67%), 18 strains of Aspergillus Niger (8.00%), 6 strains of Aspergillus sydowii (2.67%), 5 strains of Aspergillus nestoris (2.22%) and 41 strains of other filamentous fungi (18.22%). The correct rate of invasive fungi identification was 75.66% (373/493). Conclusion The most common invasive fungal infections were Candida-dominated yeasts and Aspergillus-dominated filamentous fungi. The combination of microbial mass spectrometry identification and ITS/CaM region sequencing could effectively improve the identification accuracy of fungi and provide a reference for clinical treatment of invasive fungi.

Key words: invasive fungi, yeast fungi, filamentous fungi, distribution characteristics

CLC Number:

R379

LI Fang, LI zhi-rong, ZHAO Jian-hong, ZHAO Ying, ZHANG Yan-hai, DONG Ai-ying, LIU Jin-lu, GUO Yan-yan, SUN Yan, ZHAO Wen-shen, XIE Shou-jun, WEI Hong-lian, ZHANG Jin-yan, REN Hong-tao, WANG Jian-sheng, WU Xiang-kun, GUANG Xiao, LI Dong-qing, DU Hong-li, GUO Ying-hui, XU Ying-chun, XIAO Meng, YANG Wen-Hang, XU Xiao-lin. Distribution characteristics of invasive fungal infections in Hebei province from 2016 to 2017[J]. Chinese Journal of Mycology, 2019, 14(5): 257-263.

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