Abstract:

Objective To investigate the clinical curative effect and fungal clearance effect of Chinese medicine TaXi power in the treatment of tinea pedis. Methods One hundred and sixty-seven cases were randomly divided into two groups. The treatment group included 83 cases were treated by TaXi power liquid and sertaconazole nitrate cream topically twice a day for 4 weeks. The control group included 84 cases were treated by sertaconazole nitrate cream topically twice a day for 4 weeks. Visits were scheduled on preliminary diagnosis,4,6 weeks after treatment. The scores of the symptoms and signs, the effect onset time, the effective rate and the fungal clearance rate were compared respectively. The minimum inhibitory concentrations of Trichophyton rubrum, Trichophyton mentagrophytes and Candida albicans were tested by microdilution method. Result The effective rate of the treatment group was 92.8%. The effective rate of the control group was 82.1%. There were significant differences between the two groups (P<0.05). The effect onset time of the treatment group was shorter than that of the control group(P<0.05). The fungal clearance rate of the treatment group was higher than that of the control group(P<0.05) TaXi power had inhibitory effects on Candida albicans, Trichophyton rubrum and Trichophyton mentagrophytes in vitro. The MICs were 0.125 g/mL, 0.5 g/mL and 0.25 g/mL. Conclusion TaXi power in the treatment of tinea pedis has exactly clinical curative effect. It has an inhibitory effect on common superficial fungi, and it can be promoted and applied in clinic.

Key words: TaXi power, sertaconazole, tinea pedis