Abstract:

Objective To analyse the clinical efficacy and safety of intravenous injection voricanazole and intravenous injection fluconazole in preventing fungal infection by meta analysis. Method Voricanazole group was the experimental group and fluconazole group was the control group. The randomized controlled trials (RCTs) were retrieved from China National Knowledge Infrastructure (CNKI)、WanFang and VIP Database and references listed in all studies. RCTs meeting inclusive studies were included. The data was extracted, the quality was evaluated and cross-checked by two reviews independently according to Cochrane Handbook for Systematic Reviews of Interventions. Then Meta-analysis were conducted using Stata14.0 software. Results A total of 19 studies and 1492 patients were included. Voriconazole had a better effect and lower adverse events, the difference was statistically significant.(RR=1.20,95%CI=1.14-1.26,P<0.001 AND RR=0.76,95%CI=0.65-0.90,P=0.001,respectively.) Voriconazole also had statistically better effects on the control of infection fever and the clearance of fungi (RR=1.63,95%CI=1.40-1.90,P<0.001 AND RR=1.27,95%CI=1.13-1.44,P<0.001,respectively). Conclusion Meta analysis showed that voriconazole had better effect and prognosis and lower adverse events in preventing fungal infection than fluconazole. voriconazole; fluconazole; fungal infection; randomized controlled trial; meta-analysis

Key words: voriconazole, fluconazole, fungal infection, randomized controlled trial, meta-analysis