Clinical value of G test in invasive candidiasis

Abstract

Abstract:

Objective To explore the diagnostic value of G test in invasive candidiasis (IC) and its relationship with neutrophils, pathogen, and body temperature in patients. Methods Fifty-five patients with IC, 42 patients with invasive aspergillosis(IA), 30 cases of Candida mucosa colonizer, 50 healthy people were collected from September 2015 to June 2018 in Wuyi Traditional Chinese Medicine Hospital Affiliated of Ji nan University, the level of G test were detected by immuneturbidimetry. Diagnostic value of G test in IC patients was assessed by ROC analysis. The relationships between positive rate of G test and neutrophils, pathogen, body temperature in patients with IC were also compared. SPSS19.0 was used for statistical analysis. Results The level of G test in IC patients was significantly higher than these of healthy people, Candida colonizers and IA patients(P<0.05). Among 55 patients with IC, the number of non-Candida albicans (32 cases) was higher than that of Candida albicans (23 cases). Non-IFD group and non-IC group were used as the control group, the area under the ROC curve (AUC) of the G test diagnostic IC patients was 0.899 and 0.782. The positive rate of G test in IC patients with neutrophil normal group was not significant different from those of neutrophil increase group and neutrophil reduction group (P>0.05), but it was significantly higher than that of neutrophil deficiency group (P<0.05).The positive rate of G test in Candida albicans group was not significantly different from that in the Candida tropicalis and Candida glabrata group (P>0.05), but significantly higher than that in other Candida infection group(P<0.05). There were no significant differences in the positive rate of G test between IC patients in different temperature groups(P>0.05). Conclusion G test has high diagnostic value in IC patients. It can distinguish Pathogenic bacteria and colonization bacteria, and has certain value for the identification of IC and IA. The positive rate of G test is related to the neutrophil deficiency and the type of pathogen, and not related to body temperature in IC patients.

Key words: G test, candidiasis, aspergillosis, invasion, diagnosis

CLC Number:

SHEN Wang, YANG Wen-li, YEL-yan, TAN X-yu, HUANGC-juan, ZHANG Xin. Clinical value of G test in invasive candidiasis[J]. Chinese Journal of Mycology, 2019, 14(2): 78-82.

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