Abstract:

Objective To analyze the pathogenicity and drug susceptibility test based on blood culture fungal positive specimens, and to explore the clinical and laboratory characteristics of Candida in bloodstream infection. Methods The clinical data of blood culture were collected from June 2012 to September 2018 in our hospital. The fungal species, positive alarm time (TTP), specimen delivery department, pathogen source and fluconazole susceptibility test results were analyzed. Results Eighty-six strains of fungi were isolated from blood culture, 50 strains were non-repetitive isolates, and 44 strains were Candida spp. The top three Candida species were Candida albicans with 18 strains(40.91%), Candida parapsilosis and Candida glabrata with 10 strains respectively (22.73%); and Candida parapsilosis TTP[(56.14±7.22)h] is the longest, Candida tropicalis TTP[(19.36 ± 1.24) h] is the shortest, Candida albicans[(34.67 ± 2.98) h] and Candida glabrata[(38.16 ± 4.12) h] TTP in the middle; The top three departments of candidiasis was neurosurgery with 10 strains (22.73%), tumor hematology with 6 strains (13.64%), and intensive care unit with 5 strains (11.36%);urinary system was the most common source of infection, followed by abdominal drainage infection and catheter infection; Candida and Candida tropicalis were sensitive to fluconazole at 100%, Candida albicans and Candida glabrata were 88.89% and 70%, respectively, one strain of C.kruseii was resistant and one strain of Saccharomyces cerevisiae was sensitive. Conclusion The most common bloodstream infection of Candida in hospital is Candida albicans, followed by Candida parapsilosis and Candida.

Key words: Candida, bloodstream infection, TTP