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Chinese Journal of Mycology 2019, Vol. 14  Issue (1): 16-19.

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The distribution and drug resistance rate of 3759 cases of fungal keratitis

WANG Qian, LUO Dan, CHEN Hua-bo, SUN Xiao-yan   

  1. State Key Laboratory Cultivation Base, Shandong Provincial key laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, 266071, China
  • Received:2018-06-15 Online:2019-02-28 Published:2019-02-28

Abstract:

Objective To investigate the pathogenic fungi distribution and drug resistance rate of fungal corneal infection, and to provide reference for clinical diagnosis and treatment. Method Retrospectively analyzed 3759 cases of keratitis patients in Qingdao eye hospital from January 2014 to December 2017. The keratitis patients datas were selected for fungal culture and drug resistance test, the results were collected and analyzed. Results The total positive rate was 22%(828 cases). Most of patients were old men, the most common fungi were Fusarium sp(41%), followed by Alternaria sp(30%). The positive rate of fungal culture in the fourth quarter of the year was significantly higher than those in the other quarters. The drug resistance rates of voriconazole, amphotericin B, itraconazole, ketoconazole and fluconazole were 1.2%, 1.6%, 17.6%, 32% and 96.1%. Conclusion Fungal infection of the cornea was on the rise and seasonal variation. The majority pathogens of fungal keratitis were Fusarium sp,followed by Alternaria sp. The drug resistance rates of fluconazole and ketoconazole were higher than that of other three antifungal drugs.

Key words: keratitis, fungus, changes, drug resistance

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