Diagnosis value of combined detection of serum PCT and plasma 1,3-β-D-glucan in the autoimmune diseases with invasive pulmonary fungal infection

Abstract

Abstract:

Objective To investigate the diagnosis value of combined detection of serum calcitonin (PCT) and plasma 1,3-β-D-glucan in the autoimmune disease (AID) with invasive pulmonary fungal infection (IPFI). Methods Forty five patients with AID and IPFI were selected as the case group, and 50 patients with AID were selected as the control group at the same time. Levels of serum PCT and plasma 1,3-β-D-glucan in the two groups were detected. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of serum PCT and 1,3-β-D-glucan in AID with IPFI. Results Levels of serum PCT and plasma 1,3-β-D-glucan in the case group were higher than those in the control group (P<0.05). The ROC curves showed that the diagnostic cut-off point of serum PCT was 0.05 ng/mL, and the AUC was 0.713 while those of 1,3-β-D-glucan were 20 ng/mL and 0.851, respectively. The AUC of combined diagnosis was 0.936. The accuracy, sensitivity and specificity of combined diagnosis of AID with IPFI (92.63%, 93.33% and 92.0%) were significantly higher than those of serum PCT (72.63%, 72.63% and 76.0%) (P<0.05). The accuracy of combined diagnosis was higher than that of plasma 1,3-β-D-glucan (81.05%) (P<0.05), and there was no significant difference in the other (P>0.05). Conclusion Combined detection of serum PCT and plasma 1,3-β-D-glucan is of good diagnostic efficacy for AID with IPFI.

Key words: invasive pulmonary fungal infection, calcitonin, 1,3-β-D-glucan, diagnostic efficacy

CLC Number:

R519
R446.5

CHEN Rong, LIU Min, ZHANG Wei. Diagnosis value of combined detection of serum PCT and plasma 1,3-β-D-glucan in the autoimmune diseases with invasive pulmonary fungal infection[J]. Chinese Journal of Mycology, 2018, 13(6): 335-339.

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