Phosphopantetheinyl transferases in fungi and bacteria research

Abstract

Abstract:

Phosphopantetheinyl transferases (PPTases) catalyze the post-translational modification reactions of acyl carrier protein (ACP) and peptidyl carrier protein (PCP), carrier proteins of fatty acid synthase (FAS), polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS). Phosphopantetheinyl groups on coenzyme A (CoA), are transferred to conserved serine residues of ACP and PCP to stimulate their activity, therefore fatty acids, polyketides, non-ribosomal peptides are synthesized. PPTase exists in most fungi and bacteria, and it plays an important role in biological metabolism. Now the research progress is elaborated.

Key words: Phosphopantetheinyl transferases, fungi, bacteria

CLC Number:

R379
R378

MENG Ling-ning, LIU Jin-yan, ZHAO Yue, LV Jie, LIN Yi-jing, XIANG Ming-jie. Phosphopantetheinyl transferases in fungi and bacteria research[J]. Chinese Journal of Mycology, 2018, 13(5): 305-308.

References

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