Research progress in the diagnosis and treatment of Pneumocystis pneumonia

Abstract

Abstract:

Objective To review the progress in the diagnosis and treatment of Pneumocystis pneumoniae (PCP). Methods The progress of PCP diagnosis and treatment was summarized by literature retrieving and analyzing literature. Results The clinical diagnosis of PCP is mainly based on the basic condition of immunodeficiency or immune suppression, and typical clinical and imaging manifestations, and the definite diagnosis depends on etiological examination. In recent years, many studies have shown that PCR and serum (1,3)-beta-D-glucan assay are helpful to the early diagnosis of PCP and to distinguish colonization and infection of Pneumocystis. Compound sulfamethoxazole (SMZco) is the preferred drug for the treatment of PCP, in addition, caspofungin was combined with SMZco to treat PCP in recent years, but its value in PCP treatment remains to be further studied. Conclusion The diagnosis of PCP mainly depends on clinical presentations. SMZco is the first choice for PCP treatment. Exploring the early diagnosis technology of PCP and improving the success rate of critical cases is the focus of future research.

Key words: Pneumocystis pneumonia, diagnosis, treatment

CLC Number:

R519

HE Xiao-qing, SHEN Yin-zhong. Research progress in the diagnosis and treatment of Pneumocystis pneumonia[J]. Chinese Journal of Mycology, 2018, 13(4): 247-251.

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