Literature review of skin and soft tissue infections caused by Candida spp.

Abstract

Abstract:

Objective To analyze clinical feature of skin and soft tissue infections caused by Candida spp.Methods Perform discriptive analysis of Candida infection case reports published from 1984-2017 in Pubmed, Wanfang and CNKI Database. Results Thirty-five patients in 32 literatures were analyzed. Every age group was involved worldwide, with more cases in China, roughly the same proportion of males and females. Almost all of the patients had an underlying disease or predisposing factors. Deep skin and soft tissue infections caused by Candida spp. had various clinical manifestations. More than half of cases showed skin ulcers.Facial midline area ulcers were not unusual, which could also simulate the clinical manifestations of many diseases such as folliculitis, cellulitis, necrotizing fasciitis and so on, or presented as subcutaneous abscess, skin patches, ect. All cases were confirmed by fungal culture. Pseudohyphae and (or) spores could be found in histopathological examination.Conclusion Deep skin and soft tissue infections caused by Candida spp. had various clinical features, which mostly manifested as ulcers, and could simulate a variety of diseases, easily leading to misdiagnosis. Pseudohyphae and (or) spores could be found in histopathological examination. Patients with limited lesion or mildly underlying disease had a favourable prognosis, severe underlying disease or the emergence of systematic spread could cause death. The main pathogen was Candida albicans.

Key words: Candida, Skin infection, Subcutaneous

CLC Number:

R519.3

CHEN Ping, ZHOU Ya-bin, LI Dong-ming. Literature review of skin and soft tissue infections caused by Candida spp.[J]. Chinese Journal of Mycology, 2018, 13(4): 217-222.

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