Clinical significance of plasma (1-3)-β-D glucan for diagnosis of invasive fungal infection

Abstract

Abstract:

Objective To explore the diagnostic value of plasma (1-3)-β-D-glucan test in the nosocomial invasive fungal infection (IFI). Methed The MB-80 microbial dynamics detection system was used to conduct the G test in 132 inpatients with suspected nosocomial IFI in the General Hospital of NingXia Medical University from September 2016 to April 2017. Meanwhile, the result of the conventional fungal culture and the result of combined detection were analyzed by ROC curve. Results Among 132 cases, 43 cases were diagnosed as IFI. The sensitivity of fungal culture was 67%,the specificity was 96%, PPV and NPV were 0.72 and 0.80. The sensitivity of G Test was 70%,the specificity was 88%, PPV and NPV were 0.73 and 0.86. Combined the fungal culture and G test, the sensitivity was improved to 84%,the specificity was improved to 92%. The Youden exponents of fungal culture,G test and combined detection were 0.63,0.58 and 0.76. The areas under the ROC curves of fungal culture,G test and combined detection were 0.757,0.717 and 0.798. Conclusion G test was a simple, rapidly practical early diagnostic method of fungial infection. The combined detection could increase the sensitivity,specificity and diagnostic value for diagnosing nosocomial IFI.

Key words: (1-3)-β-D-glucan, nosocomial invasive fungal infection, fungal culture

CLC Number:

R446.5
R519

Shang Yuan-yuan, Yu Nan, Dong Ling-di, Li Sha-sha, Liu Yu-xi. Clinical significance of plasma (1-3)-β-D glucan for diagnosis of invasive fungal infection[J]. Chinese Journal of Mycology, 2018, 13(3): 168-172.

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