Central nervous system phaeohyphomycosis: literature review of 203 cases

Abstract

Abstract:

Objective To review 203 central nervous system phaeohyphomycosis (CPHM) cases at home and abroad to help early diagnosis and reduce mortality. Methods Sex composition, age trait, geographical features, early clinical manifestations, associated diseases, therapies and outcome in 203 CPHM cases before August 2017 in home and abroad were collected. Results CPHM occured more commonly in immunocompetent patients than in immunedebilitated patients, predoiminantly in young and adult males. Cladophilophora bantiana was the most common etiologic agent followed by Ramichloridium mackenziei and Exophiala dermatitidis. There were no early specific symptoms of CPHM,except increased intracranial pressure. The combination of antifungal therapy and surgical resection could improve survival. However, few knowledge of CPHM and lacking specific detecting method might led to misdiagnosis or delayed treatment. An overall mortality was 80%. Conclusions With untypical features, CPHM had high mortality due to delayed diagnosis and the lack of standardized therapy.

Key words: dematiaceful fungi, phaeohyphomycosis, central nervous system (CNS)

CLC Number:

R519.8

GE Gai, LIANG Guan-zhao, SHI Dong-mei. Central nervous system phaeohyphomycosis: literature review of 203 cases[J]. Chinese Journal of Mycology, 2018, 13(3): 158-163.

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