Abstract:

Objective To assess the anti-inflammatory and anti-fungal efficacy of compound terbinafine hydrochloride gel as a topical antifungal drug for common dermatophytosis by pathological methods.Methods Guinea pig skin was infected by Trichophyton mentagrophytes to establish animal model.Treated them with four topical preparations and then investigated the recovery of their affected skin,comparing the therapeutic effect of compound terbinafine hydrochloride gel with other three formulations.Results In terms of curing guinea pig skin infected by Trichophyton mentagrophytes,compound terbinafine hydrochloride gel was more effective than terbinafine hydrochloride gel (P<0.05),triamcinolone acetonide,econazole nitrate cream (P<0.01) and mometasone furoate gel (P<0.01).Conclusions Compound terbinafine hydrochloride gel had better effect in the treatment and relapse prevention of guinea pig skin infection of Trichophyton mentagrophytes.

Key words: Trichophyton mentagrophytes, pathology, compound terbinafine hydrochloride gel