Abstract:

Objective To analyze the incidence,clinical features and the predisposing factors of fungemia,and investigate the risk factors for death due to fungemia and guide clinical treatment and hospital control.Methods The data of predisposing factors,distribution of fungus,treatment and outcomes of 74 patients with fungemia from January 2014 to March 2015 were analysed,retrospectively.The clinical data of 74 patients with fungal disease were divided into survival group and death group.Based on the results of univariate analysis,the data were analyzed using logistic multiple regression,and then the significant differences of survival group and death group were compared.Results Fungemia had many predisposing factors with high mortality rate (33/74,44.6%).Candida was the most prevalent species isolated.Univariate analysis revealed significant differences between the cured/improved cases and the fatal cases for 6 variables,including advanced age,multiple organ dysfunction syndrome (MODS),diabetes,lung infection,surgery or trauma and parenteral nutrtion therapy.Logistic multiple regression analysis showed that MODS,diabetes,surgery or trauma and parenteral nutrtion therapy were the independent risk factors for fungal septicemia-related death.Conclusion Candida spp.were the major pathogens.MODS,diabetes,surgery or trauma and parenteral nutrition therapy were the independent risk factors for fungemia related death.Isolation of pathogens,antibiotic susceptibility test and correct choice of antifungal agents in high risk patients are critical for the management of patients with fungemia infection.

Key words: fungemia, risk factors, Candida spp.