The pathogenesis of recurrent vulvovaginal candidiasis and the regulation of nuclear factor-E2-related factor 2 signaling pathway

Abstract

Abstract:

Recurrent vulvovaginal candidiasis caused by Candida albicans had complex pathogenesis.The invasion of Candida albicans and host factors were the main pathogenic factors.Among them,Candida albicans could attack the host cells and evade the host immune system to hurt the body through various ways.The nuclear factor-E2-related factor 2 signaling pathway was not only a major regulator of cell oxidation,but also an important immune regulation mechanism.On the one hand,the activation of nuclear factor-E2-related factor 2 could initiat host adaptive immunity by inhibiting the expression of NF-κB to promot Th17、Treg and Th1 cells activation;at the same time,it also could activate dendritic cells to mediate the innate immune system.Besides,Nrf2 could prevent the development of vaginitis pathway through antioxidant stress.Here,we discussed the effects of Nrf2 signaling pathway on anti-oxidative stress and immunoregulation in the pathogenesis of recurrent vulvovaginal candidiasis,it aimed to investigate the relationship between Nrf2 signaling pathway and the pathogenesis of recurrent vulvovaginal candidiasis,so as to guide the clinic treatment of recurrent vulvovaginal candidiasis.

Key words: recurrent vulvovaginal candidosis, immune, Nrf2 signaling pathway

CLC Number:

R519.3

DAI Xin-yue, MO Zi-yin, JIANG Na, GAO Ai-li, ZHU Hui-lan. The pathogenesis of recurrent vulvovaginal candidiasis and the regulation of nuclear factor-E2-related factor 2 signaling pathway[J]. Chinese Journal of Mycology, 2017, 12(4): 240-243,232.

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