The effects of NLRP3 inflammasome in fungal infection

Abstract

Abstract:

In fungal infection,host immune cells recognized pathogen associated molecular patterns (PAMPs),such as beta-glucan,by pattern recognition receptors (PRRs) and trigger innate immunity against fungi.NLRP3,a member of NLR family,together with ASC and caspase-1,constituting NLRP3 inflammasome,participated in or controls fungal infection.In this paper,we reviewed the role of NLRP3 inflammasome in the fungal infection in recent years.

Key words: Candida albicans, NLRP3 inflammasome, innate immunity, pattern recognition receptors (PRRs), pathogen associated molecular patterns (PAMPs)

CLC Number:

R519

XU Zhi-qing, WU Da-qiang, SHAO Jing, WANG Tian-ming, WANG Chang-zhong. The effects of NLRP3 inflammasome in fungal infection[J]. Chinese Journal of Mycology, 2017, 12(3): 162-167.

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