Clinical values of (1, 3)-β-D-glucan in cerebrospinal fluid of patients with fungal meningitis

Abstract

Abstract:

Objective To evaluate the utility of (1, 3)-β-D-glucan (BDG)as an assist diagnostic tool for patients infected with fungal meningoencephalitis.To investigate the change of BDG level following the administration of antifungal drug in fungal meningoencephalitis patients, evaluate the monitor value of BDG in cerebrospinal fluid (CSF) for fungal meningoencephalitis.Methods BDG concentrations of 10 cerebrospinal fluid (CSF) specimens from confirmed cases of fungal meningoencephalitis, and 30 negative control CSF specimens were tested.And we also assessed whether BDG levels correlate with clinical status by using incident samples from 10 patients with serially collected CSF.Results The level of BDG in CSF was obviously rise in those confirmed cases of fungal meningoencephalitis, the data had a statistically significant difference (P<0.05).Patients with serially collected CSF displayed that patients with a decline in CSF BDG had clinical improvement.Conclusions Our data suggest that measuring BDG in CSF is a highly sensitive test for diagnosis of fungal meningoencephalitis.Analysis of BDG levels in serially collected CSF demonstrated that BDG may correlate with clinical response and course of treatment.Routine measurement of BDG in CSF may provide useful adjunctive data for the clinical management of patients with meningoencephalitis.

Key words: (1-3)-β-D-Glucan, fungal meningoencephalitis, MB-80rapid microbial monitoring system

CLC Number:

R446.5

WANG Xing, YANG Liu, HE Xi, ZHANG Min. Clinical values of (1, 3)-β-D-glucan in cerebrospinal fluid of patients with fungal meningitis[J]. Chinese Journal of Mycology, 2017, 12(2): 86-88,91.

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