The resistance mechanisms of the biofilm related Candida albicans

Abstract

Abstract:

Candida albicans can form biofilms on medical implant materials, leading to high mortality infection.Mature biofilm related C.albicans infections are difficult to cure because of multi-drug resistance.This review discusses the resistance mechanisms of biofilm related C.albicans from efflux pump genes and matrix and stress response, summarizing the research advance of the mechanism and providing reference for clinical prevention strategies.

Key words: Candida albicans, biofilm, resistance mechanism, matrix

CLC Number:

R379.4

MENG Ling-ning, LIU Jin-yan, LI Wen-jing, ZHAO Yue, XIANG Ming-jie. The resistance mechanisms of the biofilm related Candida albicans[J]. Chinese Journal of Mycology, 2017, 12(2): 124-127.

References

[1] Truong T,Zeng G,Qingsong L,et al.Comparative ploidy proteomics of Candida albicans biofilms unraveled the role of the AHP1 gene in the biofilm persistence against amphotericin B[J].Mol Cell Proteomics,2016,15(11):3488-3500.
[2] 张慧,孙红英.生物膜中白念珠菌的耐药性研究[J].中国感染与化疗杂志,2014,14(4):361-364.
[3] Mukherjee PK,Chandra J,Kuhn DM,et al.Mechanism of fluconazole resistance in Candida albicans biofilms:phase-specific role of efflux pumps and membrane sterols[J].Infect Immun,2003,71(8):4333-4340.
[4] 刘东妹,满旭,李春莉,等.TAC1与外排泵基因对白念珠菌生物膜形成的影响[J].中国皮肤性病学杂志,2014,28(5):467-471.
[5] Li R,Kumar R,Tati S,et al.Candida albicans flu1-mediated efflux of salivary histatin 5 reduces its cytosolic concentration and fungicidal activity[J].Antimicrob Agents Chemother,2013,57(4):1832-1839.
[6] Puri S,Kumar R,Chadha S,et al.Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis[J].PLoS One,2012,7(11):e46020.
[7] 章珍珍,夏金萍,马鸣,等.白念珠菌RAS1基因高表达菌株的构建及鉴定[J].口腔生物医学,2016,7(2):72-75.
[8] Shinde RB,Chauhan NM,Raut JS,et al.Sensitization of Candida albicans biofilms to various antifungal drugs by cyclosporine A[J].Ann Clin Microbiol Antimicrob,2012,11:27.
[9] Robbins N,Uppuluri P,Nett J,et al.Hsp90 governs dispersion and drug resistance of fungal biofilms[J].PLoS Pathog,2011,7(9):e1002257.
[10] Borghi E,Borgo F,Morace G.Fungal biofilms:update on resistance[J].Adv Exp Med Biol,2016,931:37-47.
[11] Mitchell KF,Zarnowski R,Sanchez H,et al.Community participation in biofilm matrix assembly and function[J].Proc Natl Acad Sci USA,2015,112(13):4092-4097.
[12] Martins M,Uppuluri P,Thomas DP,et al.Presence of extracellular DNA in the Candida albicans biofilm matrix and its contribution to biofilms[J].Mycopathologia,2010,169(5):323-331.
[13] Johnson CJ,Cabezas-Olcoz J,Kernien JF,et al.The extracellular matrix of Candida albicans biofilms impairs formation of neutrophil extracellular traps[J].PLoS Pathog,2016,12(9):e1005884.
[14] Nett J,Lincoln L,Marchillo K,et al.Putative role of beta-1,3 glucans in Candida albicans biofilm resistance[J].Antimicrob Agents Chemother,2007,51(2):510-520.
[15] Nett JE,Crawford K,Marchillo K,et al.Role of Fks1p and matrix glucan in Candida albicans biofilm resistance to an echinocandin,pyrimidine,and polyene[J].Antimicrob Agents Chemother,2010,54(8):3505-3508.
[16] Nett JE,Sanchez H,Cain MT,et al.Interface of Candida albicans biofilm matrix-associated drug resistance and cell wall integrity regulation[J].Eukaryot Cell,2011,10(12):1660-1669.
[17] Taff HT,Nett JE,Zarnowski R,et al.A Candida biofilm-induced pathway for matrix glucan delivery:implications for drug resistance[J].PLoS Pathog,2012,8(8):e1002848.
[18] De Brucker K,Tan Y,Vints K,et al.Fungal beta-1,3-glucan increases ofloxacin tolerance of Escherichia coli in a polymicrobial E.coli/Candida albicans biofilm[J].Antimicrob Agents Chemother,2015,59(6):3052-3058.
[19] Roudbarmohammadi S,Roudbary M,Bakhshi B,et al.ALS1 and ALS3 gene expression and biofilm formation in Candida albicans isolated from vulvovaginal candidiasis[J].Adv Biomed Res,2016,5:105.
[20] Mathé L,Van Dijck P.Recent insights into Candida albicans biofilm resistance mechanisms[J].Curr Genet,2013,59(4):251-264.
[21] Nobile CJ,Fox EP,Hartooni N,et al.A histone deacetylase complex mediates biofilm dispersal and drug resistance in Candida albicans[J].MBio,2014,5(3):e01201-e012014.
[22] Xie Z,Thompson A,Sobue T,et al.Candida albicans biofilms do not trigger reactive oxygen species and evade neutrophil killing[J].J Infect Dis,2012,206(12):1936-1945.