Human genetic susceptibility to Candida infections

Abstract

Abstract:

Candida spp.are medically important fungi causing severe mucosal and systemic infections, however, not all individuals are at risk to develop Candida infections.With the completion of the human genome project and the development of molecular genetic technology, the genentic susceptibility to Candida infections has attracted the attention of more and more researchers.Severe fungal infections are associated with monogenic primary immunodeficiencies such as defects in STAT1, STAT3 or CARD9.Furthermore, some polymorphisms in genes of the immune system have also been associated with fungal infections such as recurrent vulvovaginal candidiasis and candidemia.The discovery of the genetic susceptibility to Candida infections can lead to a better understanding of the pathogenesis of the disease, as well as the development of novel detection index and therapeutic target.

Key words: Candida infections, genetic susceptibility, primary immunodeficiency diseases, gene polymorphisms

CLC Number:

R519.3

KAN Si-yue, LI Xiao-fang, LIU Wei-da. Human genetic susceptibility to Candida infections[J]. Chinese Journal of Mycology, 2017, 12(2): 120-123.

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