The transcription factors of phenotypic transition signal pathways in Candida albicans

Abstract

Abstract:

Candida albicans, responsing signals to adapt to environment by a variety of signal transduction pathways, is the most common human opportunistic fungi.The most important signal transduction pathways that mediate the morphogenesis and virulence in Candida albicans are cAMP-PKA pathway and MAPK pathway.Transcription factors are the endpoints of these pathways, such as Efg1 and Cph1.Transcription factors can regulate the transcription of genes by binding with their promoters in Candida albicans.Regulating transcription factors can promote or inhibit the signal transduction, and thus affecting the proliferation, morphogenesis, virulence, etc, of Candida albicans.In this review, we demonstrated the major transcription factors of phenotypic transition signal pathways in Candida albicans to further understand the phenotype and regulation mechanism of Candida albicans.

Key words: C.albicans, phenotype, phenotypic transition, signal pathways, TF

CLC Number:

R379.4

WANG Li-hong, ZHANG Jin-yu, YAN Lan, JIANG Yuan-ying, CAO Yong-bing, HONG Hao. The transcription factors of phenotypic transition signal pathways in Candida albicans[J]. Chinese Journal of Mycology, 2017, 12(2): 114-119.

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