Clinical infection characteristics and analysis of drug resistance trend of candiduria in hospital

Abstract

Abstract:

Objective To investigate and analyze the clinical infection characteristics and drug resistance trend of candiduria, to provide evidence for selection of antifungal drugs.Methods Patients who cultured Candida positive in urinary sediment were collected from 2013 to 2016.The strains were identified by CHRO Magar chromogenic medium and the drug susceptibility test was performed with ATB Fungu 3 reagent.Results A total of 202 strains of Candida were isolated, including C.albicans (79.1%), C.tropicalis (10.7%), C.parapsilosis and C.krusei (respectively 5.1%).The Candida were mainly found in emergency department (83 cases), followed by urology (21 cases) and endocrinology (21 cases).Drug sensitivity results showed that Amphotericin B and 5-fluorocytosine had a strong antibacterial activity against Candida.The resistance rate of Candida to fluconazole increased year by year.Candida's resistant to voriconazole and itraconazole was in a fluctuating state, and the resistance rate of Candida was significantly higher in 2016.Conclusion C.albicans was still the most predominant pathogen of candiduria.The drug resistance rates of amphotericin B and 5-fluorocytosine were the lowest, while there was a genus difference in drug resistance of the azoles, and the trends of drug resistance were becoming more serious.

Key words: Candida, candiduria, drug resistance

CLC Number:

R519.3

CAO Yan-yun, FANG Hua, CAI Hai-bin, XU Shun-ming. Clinical infection characteristics and analysis of drug resistance trend of candiduria in hospital[J]. Chinese Journal of Mycology, 2017, 12(2): 102-105.

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