Abstract:

Objective To observe the efficacy and safety of once-daily luliconazole cream in treatment of pityriasis versicolor.Methods There were 80 patients with pityriasis versicolor randomly enrolled into trial group treated with luliconazole cream (once daily) for 2 weeks and into control group treated with 2% ketaconazole cream (twice daily) for 2 weeks.The clinical observations were taken on baseline,2 week and 6 week after the treatment.Results The clinical effective rates of 2 groups 2 week after the treatment were 54.5% and 56.3%;the mycological clearance rates of 2 groups were 81.8% and 87.5%;both results had no statistically significant difference (P>0.05).The clinical effects of 2 groups 6 week after the treatment were 63.6% and 62.5%;the mycological effects of 2 groups were 93.9% and 93.8%;both results had no statistically significant difference (P>0.05).The theraputic result of the white-type eruption obviously lower than that of the brown-type and red-type eruption.Besides,no side effects were been found in both groups.Conclusions The method of luliconazole cream once-daily for 2 weeks is effective and safe in the treatment of pityriasis versicolor.

Key words: pityriasis versicolor, luliconazole, efficacy