Efficacy and safety of superpulse-mode fractional carbon-dioxide laser combined with 1% luliconazole in the treatment of onychomycosis

Abstract

Abstract:

Objective To evaluate the efficacy and safety of superpulse-mode fractional carbon-dioxide (CO₂) laser combined with 1% luliconazole in the treatment of onychomycosis.Method A total of sixty patients with 223 onychomycotic nails were enrolled in this study and then randomly divided into two groups.The affected nails in group A were treated by superpulse-mode fractional carbon-dioxide (CO₂) laser at 2-week intervals.The affected nails in group B were treated by superpulse-mode fractional carbon-dioxide (CO₂) laser at 2-week intervals combined with daily topical application of 1% luliconazole cream under occlusion.The course of treatment is 6-month long for each group.Clinical efficacy and mycological clearance were evaluated at 3 months after the completion of treatment.Results Sixty patients completed the treatment and follow-up.In group A,among the 31 patients with 108 affected nails,the clinical efficacy was about 50.9% whereas the mycological clearance rate was about 38.9%.In group B,among the 29 patients with 115 affected nails,the clinical efficacy was about 69.6% and mycological clearance rate was about 57.4%.There were significant differences in the clinical efficacy and mycological clearance rates between both groups (P<0.05).The comprehensive satisfactory rate was about 87.1% in group A while it was about 93.1% in group B.In addition to slight tolerable pain,there were no obvious side effects noticed in both groups.Conclusions Superpulse-mode fractional carbon-dioxide (CO₂) laser combined with 1% luliconazole cream was a safe and effective method for the treatment of onychomycosis,and the clinical efficacy was much better than the laser treatment only.

Key words: onychomycosis, fractional laser, luliconazole, topical treatment

CLC Number:

R756.4

HUANG He, LI Jin, LIU Juan, ZHANG Jia-an, XU Yang, WU Di, LUO Dan, ZHOU Bing-rong. Efficacy and safety of superpulse-mode fractional carbon-dioxide laser combined with 1% luliconazole in the treatment of onychomycosis[J]. Chinese Journal of Mycology, 2016, 11(5): 298-303,297.

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