The study of expression changes of VEGFR in mice brain tissue infected with Cryptococcus neoformans

Abstract

Abstract:

Objective To investigate the expression changes of the vascular endothelial growth-factor receptors (VEGFR) in the mice brain tissus after being infected by Cryptococcus neoformans.Methods Test group mice (n=30) were injected with Cryptococcus neoformans via the tail vein,while control group mice (n=6) received saline.Western blotting technology was used in 6 h,12 h,24 h,48 h,72 h to detect VEGFR1 and VEGFR2 expression changes in mice brain tissus.Rusluts Compared with the control group,VEGFR1 and VEGFR2 protein expressions in the test group were down.There was significant difference between the test group and control group (P<0.05).Conclusions VEGFR might play protective role in brain edema caused by cryptococcal meningitis.

Key words: cryptococcal meningitis, mice model, vascular endothelial growth factor recepter

CLC Number:

R379.5

ZHENG Chong, WEN Hai, GUO Fang, FAN Yi-bin. The study of expression changes of VEGFR in mice brain tissue infected with Cryptococcus neoformans[J]. Chinese Journal of Mycology, 2016, 11(5): 257-260.

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