Dynamic changes of galactomannan and the relation with CT image in invasive pulmonary aspergillosis

Abstract

Abstract:

Objective To observe changes of galactomannan(GM) in bronchoalveolar lavage(BAL) and serum,evaluate relationship between GM and CT feature,neutrophil count in serum for invasive fungal disease(IFD).Methods Sixty patients with IFD and were enrolled in this study.The levels of GM were measured in BAL and serum.Univariate logistic regression analysis was performed with GM in BAL and lung lobe number,air crescent sign,halo sign,in CT feature and neutrophil in serum.Result GM in BAL was higher than the GM in serum(0.62±0.08 mg/L,60.0%;0.51±0.07 mg/L,31.6%) before antifungal treatment,compared with before antifungal treatment,the GM in BAL in 1 m 2 m 3 m 6 m decreasd rapidly after antifungal treatment(P<0.05),but the GM of serum decrease slowly,decreasing only in 3 m,6 m(P<0.05).The positive rate of the GM of BAL was in concerned with the amount of invasive lung lobe and halo sign in CT and neutrophil count in serum.Conclusion GM in BAL might be a important marker for diagnosing and efficacy in IFD,GM in BAL was correlated with CT feature and neutrophil count.

Key words: invasive fungal disease, bronchoalveolar lavage, galactomannan

CLC Number:

R519.8

GONG Zheng, ZHAN Ming, ZHANG Ling-yun, GONG Ping, WANG Yan-hua, CUI Cong, WANG Yong-quan, XIANG Guang-ming, CHEN Shi-xiong. Dynamic changes of galactomannan and the relation with CT image in invasive pulmonary aspergillosis[J]. Chinese Journal of Mycology, 2016, 11(4): 205-208.

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