Synergistic effect of rifapentine with fluconazole against FLC-resistance Candida albicans

Abstract

Abstract:

Objective To explore the in vitro synergistic effect of rifapentine with fluconazole on FLC-resistance Candida albicans.Methods The minimal inhibitory concentrations (MIC) of rifapentine and fluconazole against Candida albicans were detected by method of Clinical and Laboratory Standards Institute (CLSI) M27-A2 microdilution.The effects of rifapentine and fluconazole against Candida albicans in vitro were valued by broth microdilution checkerboard technique system.Results In the antifungal susceptibility assay,there was no antimicrobial activity of rifapentine single used against the 12 strains of Candida albicans (MIC>1 024 μg/mL).The combined of rifapentine and fluconazole didn't display synergistic effect on the FLC-sensitive Candida albicans (FICI>0.5),however,it had a significant synergistic effect on the FLC-resistance Candida albicans (FICI<0.1).Conclusion Rifapentine alone demonstrated no antifungal activity,but rifapentine can significantly enhance the effect of fluconazole against FLC-resistance Candida albicans.

Key words: Canidia albicans, rifapentine, fluconazole, synergism

CLC Number:

R978.5

WANG Yu-lian, ZHANG Lu-lu, QIN Yu-lin, CAO Yong-bing, WU Jian-hua. Synergistic effect of rifapentine with fluconazole against FLC-resistance Candida albicans[J]. Chinese Journal of Mycology, 2016, 11(3): 156-159.

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