Abstract:

Objective To research the anti-fungal spectrum and activity of the 1% luliconazole cream compared with other three creams that contain of 2% ketoconazole, of 1% terbinafine, of 1% naftifine -0.25% ketoconazole cream respectively.Methods Thirty-two isolates of pathogenic fungi belonging to 14 species isolated from clinic and three species of Malassezia standard stains were enrolled into the experiment.The agar diffusion method was used to judge drug sensitivity.Organism suspension of each species was spread on the surface of the plate of the optimal media containing 2% agar.Then wells were made in the plate and four types of cream were put in each well respectively.After seven-day incubation, the diameter of the inhibition zone around the well full of each cream was observed and recorded.Results The inhibition zone around the well filled with 1% luliconazole cream for all experiment isolates was observed, with the mean diameter of 50.35 mm.Similarly, the mean diameter of inhibition zone of 1% naftifine -0.25% ketoconazole cream for all experiment isolates was 52.46 mm.About 1% terbinafine cream, the mean diameter was 49.24 mm but there was no inhibition zone observed around Candida spp.and Fusarium solani.As for 2% ketoconazole cream, the mean diameter was 33.22 mm but there was no inhibition zone observed around Fusarium solani.There were no significant significances for mean diameters of the inhibition zone when comparing 1% luliconazole cream with 1% naftifine -0.25% ketoconazole cream, but when comparing 1% luliconazole cream with 2% ketoconazole cream and 1% terbinafine cream, the difference was statistically significant (P=0.000).Conclusion The anti-fungal spectrum and activity of 1% luliconazole cream are nearly the same as that of 1% naftifine -0.25% ketoconazole cream, and is stronger than that of 2% ketoconazole cream and 1% terbinafine cream.

Key words: 1% luliconazole cream, anti-fungal spectrum, anti-fungal activity, in vitro